Abstract
DNA replication can occur throughout the nucleus and is not restricted to the inner surface of the nuclear membrane.
Similar content being viewed by others
References
Jacob, F., Brenner, S., and Cuzin, F., Cold Spring Harbor Symp. Quant. Biol., 28, 329 (1963).
Ganesan, A. T., and Lederberg, J., Biophys. Biochem. Res. Commun., 18, 824 (1965).
Smith, D. W., and Hanawalt, P. C., Biochim. Biophys. Acta, 149, 519 (1967).
Tremblay, G. Y., Daniels, M. J., and Schaechter, M., J. Mol. Biol., 40, 65 (1969).
Sueoka, N., and Quinn, W. G., Cold Spring Harbor Symp. Quant. Biol., 33, 695 (1968).
Fuchs, E., and Hanawalt, P. C., J. Mol. Biol., 52, 301 (1970).
Fielding, P., and Fox, C. F., Biochem. Biophys. Res. Commun., 41, 157 (1970).
Friedman, D. F., and Mueller, G. C., Biochim. Biophys. Acta, 174, 253 (1969).
Mizuno, N. S., Stoops, C. D., and Sinha, A. A., Nature New Biology, 229, 22 (1971).
Hanaoka, F., and Yamada, M., Biochem. Biophys. Res. Commun., 42, 647 (1971).
Pearson, G. D., and Hanawalt, P. C., J. Mol. Biol., 62, 65 (1971).
Smith, B. J., J. Mol. Biol., 47, 101 (1970).
O'Brien, R. L., Sanyal, A. B., and Stanton, R. H., Exp. Cell Res., 70, 106 (1972).
Comings, D. E., and Kakefuda, T., J. Mol. Biol., 33, 225 (1968).
Blondel, B., Exp. Cell Res., 53, 348 (1968).
Williams, C. A., and Ockey, C. H., Exp. Cell Res., 63, 365 (1970).
Erlandson, R. A., and de Harven, E., J. Cell Sci., 8, 353 (1971).
Kay, R. R., Haines, M. E., and Johnston, I. R., FEBS Lett., 16, 233 (1971).
Huberman, J. A., and Riggs, A. D., J. Mol. Biol., 32, 327 (1968).
Caro, L. G., and Van Tubergen, R. P., J. Cell Biol., 15, 173 (1962).
Stubblefield, E., in Methods in Cell Physiology (edit. by Prescott, D. M.), 3, 25 (Academic Press, New York, 1968).
Ockey, C. H., Exp. Cell Res., 70, 203 (1972).
Tobia, A. M., Schildkraut, C. L., and Maio, J. J., Biochim. Biophys. Acta, 246, 258 (1971).
Bostock, C. J., and Prescott, D. M., Exp. Cell Res., 64, 267 (1971).
Flamm, W. G., Bernheim, N. J., and Brubaker, P. E., Exp. Cell Res., 64, 97 (1971).
Lima-de-Faria, A., and Javorska, H., Nature, 217, 138 (1968).
Brown, S. W., Science, 151, 417 (1966).
Fakan, S., Turner, G. N., Pagano, J. S., and Hancock, R., Proc. US Nat. Acad. Sci., 69, 2300 (1972).
Lenk, R., and Penman, S., J. Cell Biol., 49, 541 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HUBERMAN, J., TSAI, A. & DEICH, R. DNA Replication Sites within Nuclei of Mammalian Cells. Nature 241, 32–36 (1973). https://doi.org/10.1038/241032a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/241032a0
- Springer Nature Limited
This article is cited by
-
Nuclear matrix-bound replicational sites detected in situ by 5-bromodeoxyuridine
Histochemistry (1992)
-
DNA synthesis progression in 3T3 synchronized fibroblasts: a high resolution approach
Histochemistry (1992)
-
Cytometric analysis of DNA replication inhibited by emetime and cyclosporin A
Histochemistry (1991)
-
Immunofluorescent visualization of DNA replication sites within nuclei of Chinese hamster ovary cells
Histochemistry (1989)
-
The nuclear matrix — Its role in the spatial organization and replication of eukaryotic DNA
Molecular Biology Reports (1987)