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A frameshift mutation in MC4R associated with dominantly inherited human obesity

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Figure 1: A frameshift mutation in MC4R is associated with dominantly inherited obesity.
Figure 2: Auxology for subjects heterozygous for a frameshift mutation in MC4R.

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Acknowledgements

We thank G. Cook for her help in establishing the patient cohort and the many clinicians who have referred patients to us. S.O.R. & I.S.F are supported by the Wellcome Trust.

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Author notes

  1. Richard G. Stanhope: Institute of Child Health and Great Ormond Street Hospital , London, U.K. *G.S.H.Y. and I.S.F. contributed equally to this work.

Authors and Affiliations

  1. University Departments of Medicine and Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, UK

    Giles S.H. Yeo *, I. Sadaf Farooqi *, Shiva Aminian, David J. Halsall & Stephen O'Rahilly

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  1. Giles S.H. Yeo *
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  2. I. Sadaf Farooqi *
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  3. Shiva Aminian
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  4. David J. Halsall
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  5. Richard G. Stanhope
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  6. Stephen O'Rahilly
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Correspondence to Stephen O'Rahilly.

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Yeo, G., Farooqi, I., Aminian, S. et al. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 20, 111–112 (1998). https://doi.org/10.1038/2404

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