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Requirement for Θ-Bearing Cells in Lymphocytic Choriomeningitis Virus-induced Central Nervous System Disease

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Abstract

THE immunopathological basis of the acutely fatal convulsive central nervous system (CNS) disease produced in adult mice following cerebral infection with lymphocytic Choriomeningitis (LCM) virus is well established1. Thus, a variety of immuno-suppressive treatments, given to adult mice inoculated intracerebrally with a potentially lethal dose of virus, produce a transient or permanent ablation of both the histological and clinical correlates of LCM. Permanently protected mice usually maintain high virus concentrations in their brains and blood for life2,3, presenting a picture which, on virological grounds, is strikingly similar to the lifelong virus carrier state arising in mice inoculated with LCM virus shortly after birth3,4.

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Authors and Affiliations

  1. Departments of Epidemiology and Ophthalmology, Schools of Hygiene and Medicine, Johns Hopkins University, Baltimore, Maryland, 21205

    G. A. COLE, N. NATHANSON & R. A. PRENDERGAST

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  1. G. A. COLE
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  2. N. NATHANSON
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  3. R. A. PRENDERGAST
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COLE, G., NATHANSON, N. & PRENDERGAST, R. Requirement for Θ-Bearing Cells in Lymphocytic Choriomeningitis Virus-induced Central Nervous System Disease. Nature 238, 335–337 (1972). https://doi.org/10.1038/238335a0

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  • DOI: https://doi.org/10.1038/238335a0

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