Abstract
FIBROBLASTS exhibit a locomotory behaviour in cultures on a plane surface. An undulating membrane or leading lamella forms at the frontal edge and may be the locomotory organ of the cell. When the leading lamellae of two cells collide, several events occur. The forward motion of the cells is stopped, the cells contract, the undulations of the membrane cease, and movement proceeds in a different direction. This has been termed contact inhibition of movement1. When cells become confluent, movement is considerably decreased, presumably due to contact on all surfaces, and at confluency there are restrictions on cell growth which are apparently related to the population density of the cells. This has been termed contact or density-dependent inhibition of growth2–4. At present, no strong evidence connects contact inhibition of movement and growth, but as transformation often disturbs both properties a connexion between them may exist3,5.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Abercrombie, M., and Heaysman, J. E. M., Exp. Cell Res., 6, 293 (1954).
Golde, A., Virology, 16, 9 (1962).
Todaro, G. J., Green, H., and Goldberg, B. D., Proc. US Nat. Acad. Sci., 51, 66 (1964).
Stoker, M. G. P., and Rubin, H., Nature, 215, 171 (1967).
Abercrombie, M., In Vitro, 6, 129 (1970).
Pastan, I., and Perlman, R. L., Nature New Biology, 229, 5 (1971).
Robison, G. A., Butcher, R. W., and Sutherland, E. W., Ann. Rev. Biochem., 37, 149 (1968).
Bürk, R. R., Nature, 219, 1272 (1968).
Johnson, G. S., Friedman, R. M., and Pastan, I., Proc. US Nat. Acad. Sci., 68, 425 (1971).
Hsie, A., and Puck, T. T., Proc. US Nat. Acad. Sci., 68, 358 (1971).
Sheppard, J. R., Proc. US Nat. Acad. Sci., 68, 1316 (1971).
Ryan, W. L., and Heidrick, M. L., Science, 162, 1484 (1968).
Otten, J., Johnson, G. S., and Pastan, I., Biochem. Biophys. Res. Commun. (in the press).
Pastan, I., Johnson, G. S., Otten, J., Peery, C. V., and d'Armiento, M., Fed. Proc., 30, 1047 (1971).
Peery, C. V., Johnson, G. S., and Pastan, I., J. Biol. Chem. (in the press).
Sanford, K. K., Earle, W. R., and Likely, G. D., J. Nat. Cancer Inst., 9, 229 (1948).
Morgan, W. D., and Dawe, C. J., J. Nat. Cancer Inst., 26, 133 (1961).
Morgan, W. D., In Vitro, 2, 126 (1966).
Rose, G. G., Texas Rep. Biol. Med., 12, 1074 (1954).
McQuilkin, W. T., and Earle, W. R., J. Nat. Cancer Inst., 28, 763 (1962).
Todaro, G. S., Lazar, G., and Green, H., J. Cell Comp. Physiol., 66, 325 (1965).
Gurney, T., Proc. US Nat. Acad. Sci., 62, 906 (1969).
Dulbecco, R., and Stoker, M. G. P., Proc. US Nat. Acad. Sci., 66, 204 (1970).
Baker, J. B., and Humphreys, T., Proc. US Nat. Acad. Sci. (in the press).
Carter, S. B., Nature, 213, 261 (1967).
Spooner, B. S., Yamada, K. M., and Wessells, N. K., J. Cell Biol., 49, 595 (1971).
Garbers, D. L., Lust, W. D., First, N. L., and Lardy, H. A., Biochem., 10, 1825 (1971).
Yokota, T., and Gots, J. S., J. Bact., 103, 513 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
JOHNSON, G., MORGAN, W. & PASTAN, I. Regulation of Cell Motility by Cyclic AMP. Nature 235, 54–56 (1972). https://doi.org/10.1038/235054a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/235054a0
- Springer Nature Limited
This article is cited by
-
Role of prostaglandins and cyclic nucleotides in the mechanism of development of drug-induced thrombocytopenia
Bulletin of Experimental Biology and Medicine (1993)
-
Effects of lithium and rubidium on shock-induced changes in open-field activity
Psychopharmacology (1986)
-
Lithium effects on active and passive avoidance behavior in the rat
Psychopharmacology (1983)
-
Effect of glucocorticoid treatment on the excitability of rat skeletal muscle
Pfl�gers Archiv European Journal of Physiology (1982)