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Mouse Specific Bone Marrow-derived Lymphocyte Antigen as a Marker for Thymus-independent Lymphocytes

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Abstract

THE usefulness of the theta (θ) alloantigen as a marker for thymus-derived lymphocytes in mice1–6 has emphasized the need for a distinguishing marker for thymus-independent (bone marrow-derived) lymphocytes, about which relatively little is known. We have raised an antiserum in a rabbit against lymph node cells from mice which had been thymectomized, irradiated and reconstituted with foetal liver cells, which after appropriate absorption was cytotoxic only to those lymphoid cells which were thymus-independent. Because the cell surface antigen(s) with which the antiserum is principally reacting seems to be species-specific, we have followed the example of Shigeno et al.7 and have called it MBLA (mouse-specific bone marrow-derived lymphocyte antigen).

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References

  1. Raff, M. C., Nature, 224, 378 (1969).

    Article  ADS  CAS  Google Scholar 

  2. Schlesinger, M., and Yron, I., Science, 164, 1412 (1969).

    Article  ADS  CAS  Google Scholar 

  3. Raff, M. C., Nature, 226, 1257 (1970).

    Article  ADS  CAS  Google Scholar 

  4. Schimpl, A., and Wecker, E., Nature, 226, 1258 (1970).

    Article  ADS  CAS  Google Scholar 

  5. Greaves, M. F., and Möller, E., Cell. Immunol. (in the press).

  6. Raff, M. C., and Owen, J. J. T., Europ. J. Immunol. (in the press).

  7. Shigeno, N., Arpels, C., Hämmerling, U., Boyse, E. A., and Old, L. J., Lancet, ii, 320 (1968).

  8. Raff, M. C., and Wortis, H. H., Immunology, 18, 929 (1970).

    Google Scholar 

  9. Miller, J. F. A. P., and Mitchell, G. F., J. Exp. Med., 128, 801 (1968).

    Article  CAS  Google Scholar 

  10. Takahashi, T., Old, L. J., and Boyse, E. A., J. Exp. Med., 131, 1325 (1970).

    Article  CAS  Google Scholar 

  11. Asakuma, R., and Reif, A. E., Cancer Res., 28, 707 (1968).

    CAS  PubMed  Google Scholar 

  12. Iversen, J. G., Clin. Exp. Immunol., 6, 101 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Colley, D. G., Malakian, A., and Waksman, B. H., J. Immunol., 104, 585 (1970).

    CAS  PubMed  Google Scholar 

  14. Hellström, I., Hellström, K. E., Pierce, G. E., and Young, J. P. S., Nature, 220, 1352 (1968).

    Article  ADS  Google Scholar 

Download references

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Authors and Affiliations

  1. National Institute for Medical Research, Mill Hill, London, NW7

    M. C. RAFF, S. NASE & N. A. MITCHISON

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  1. M. C. RAFF
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  2. S. NASE
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  3. N. A. MITCHISON
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RAFF, M., NASE, S. & MITCHISON, N. Mouse Specific Bone Marrow-derived Lymphocyte Antigen as a Marker for Thymus-independent Lymphocytes. Nature 230, 50–51 (1971). https://doi.org/10.1038/230050a0

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