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Properties, Structure and Possible Neuroreceptor Role of the Encephalitogenic Protein of Human Brain

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Abstract

The principal determinant region of the encephalitogenic protein, the amino-acids of which have been sequenced, is located round the sole tryptophan residue. The determinant may be the receptor site for 5-hydroxytryptamine in certain regions of the central nervous system, and the paralysis in experimental autoimmune encephalomyelitis may be caused by an immunopharmacological block of nervous transmission.

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Authors and Affiliations

  1. Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria, 3052

    P. R. CARNEGIE

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  1. P. R. CARNEGIE
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CARNEGIE, P. Properties, Structure and Possible Neuroreceptor Role of the Encephalitogenic Protein of Human Brain. Nature 229, 25–28 (1971). https://doi.org/10.1038/229025a0

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  • DOI: https://doi.org/10.1038/229025a0

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