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Increased Frequency of Deletions in DNA Polymerase Mutants of Escherichia coli

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Abstract

Mutants of E. coli, deficient in DNA polymerase activity in vitro, spontaneously generate chromosomal deletions at a high frequency. Such deletions may arise from the inability of these strains to repair single-strand breaks in DNA efficiently.

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COUKELL, M., YANOFSKY, C. Increased Frequency of Deletions in DNA Polymerase Mutants of Escherichia coli. Nature 228, 633–635 (1970). https://doi.org/10.1038/228633a0

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  • DOI: https://doi.org/10.1038/228633a0

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