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Theory for the Mechanism of Chloroquine Resistance in Rodent Malaria

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Abstract

The appearance of succinate dehydrogenase in the chloroquine resistant parasite suggests that resistance is acquired by a switch in the respiratory pathway to the citric acid cycle.

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Authors and Affiliations

  1. Department of Parasitology, Liverpool School of Tropical Medicine,

    R. E. HOWELLS & W. PETERS

  2. MRC Research Group on the Chemotherapy of Protozoal Diseases and Drug Resistance, Department of Parasitology, Liverpool School of Tropical Medicine,

    C. A. HOMEWOOD & D. C. WARHURST

Authors
  1. R. E. HOWELLS
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  2. W. PETERS
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  3. C. A. HOMEWOOD
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  4. D. C. WARHURST
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HOWELLS, R., PETERS, W., HOMEWOOD, C. et al. Theory for the Mechanism of Chloroquine Resistance in Rodent Malaria. Nature 228, 625–628 (1970). https://doi.org/10.1038/228625a0

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  • DOI: https://doi.org/10.1038/228625a0

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