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Evidence for Interaction in vitro of Morphine with Glutathione

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Abstract

THE significance of glutathione in the metabolic activity and structural integrity of cells, in the maintenance of protein SH groups, and its function in electron-transferring systems, as a coenzyme or as part of prosthetic group of other enzymes, is well known. The cerebral tissue of several mammalian species contains a fairly high concentration of reduced glutathione1. Drugs which cause an alteration in the level of reduced glutathione in brain or in its interaction with essential sulphydryl groups are known to influence the activity of neurones in the central nervous system2. Evidence for possible interaction in vitro of morphine with glutathione to form a peptide-conjugate is presented in this communication.

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Authors and Affiliations

  1. Department of Pharmacology, School of Medicine, University of Iowa, Iowa City, Iowa, 52240

    A. L. MISRA & L. A. WOODS

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  1. A. L. MISRA
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  2. L. A. WOODS
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MISRA, A., WOODS, L. Evidence for Interaction in vitro of Morphine with Glutathione. Nature 228, 1226–1227 (1970). https://doi.org/10.1038/2281226a0

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  • DOI: https://doi.org/10.1038/2281226a0

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