Abstract
THERE have been several analyses of the role of nicotine in smoking. Johnston1 found that heavy smokers reported a pleasurable sensation when given nicotine, whereas non-smokers reported an unpleasant effect. Lucchesi et al.2 showed that intravenous administration of nicotine diminished the number of cigarettes smoked by heavy smokers. Jarvik et al.3 recently obtained a similar result with nicotine taken orally. If, as these studies suggest, nicotine is an incentive in smoking, then drugs which block the action(s) of nicotine should influence smoking.
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References
Johnston, L. M., Lancet, ii, 742 (1942).
Lucchesi, B. R., Schuster, C. R., and Emley, G. S., Clin. Pharmacol. Ther., 8, 789 (1967).
Jarvik, M. E., Glick, S. D., and Nakamura, R. K., Clin. Pharmacol. Ther. (in the press).
Jarvik, M. E., Ann. NY Acad. Sci., 142, 280 (1967).
Pybus, R., Goldfarb, T., and Jarvik, M. E., J. Exp. Anal. Behav., 12, 88 (1969).
Glick, S. D., Canfield, J. L., and Jarvik, M. E., Psychol. Rep. (in the press).
Goodman, L. S., and Gilman, A., The Pharmacological Basis of Therapeutics, 585 (Macmillan, 1965).
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GLICK, S., JARVIK, M. & NAKAMURA, R. Inhibition by Drugs of Smoking Behaviour in Monkeys. Nature 227, 969–971 (1970). https://doi.org/10.1038/227969a0
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DOI: https://doi.org/10.1038/227969a0
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