Abstract
TWO isomers of tetrahydrocannabinol (THC) are found in natural marijuana preparations. 99 per cent is in the form of Δ1(9)-THC, which is very active when taken orally or smoked1,2. A Δ3-THC homologue, synhexyl (pyrahexyl), has been found to be about one-third as active as Δ1-THC, given orally to the same individuals2. The study I report here compared measured doses of Δ1-THC, the Δ3-homologue (synhexyl), and Δ3-THC smoked by the same individuals, using a placebo and blind controls.
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References
Isbell, H., Gorodetsky, G. W., Jasinski, D., Claussen, U., v. Spulak, F., and Korter, F., Psychopharmacologia, 11, 184 (1967).
Hollister, L. E., Richards, R. K., and Gillespie, H. K., Clin. Pharmacol. Ther., 9, 783 (1968).
Song, Chung Hun, Kanter, S. L., and Hollister, L. E., Res. Comm. Chem. Path. Pharmacol., 1, 375 (1970).
Hollister, L. E., and Gillespie, H. K., Arch. Gen. Psychiat. (in the press).
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HOLLISTER, L. Tetrahydrocannabinol Isomers and Homologues: Contrasted Effects of Smoking. Nature 227, 968–969 (1970). https://doi.org/10.1038/227968a0
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DOI: https://doi.org/10.1038/227968a0
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