Abstract
RECENT investigations of peptide fractions from cobra venoms suggest that the most potent acute toxicity arises from a curare-like block of the action of acetylcholine at the skeletal myoneural junction1–3. I wish to report the effects on myoneural transmission of toxin T3 from Naja naja siamensis—(Kaouthia) (Thailand cobra) venom, a pure peptide of known amino-acid composition4.
Similar content being viewed by others
References
Meldrum, B. S., Brit. J. Pharmacol., 25, 197 (1965).
Chang, C. C., and Lee, C. Y., Brit. J. Pharmacol. Chemother., 28, 172 (1966).
Tseng, L. F., Chiu, T. H., and Lee, C. Y., Toxicol. Appl. Pharmacol., 12, 526 (1968).
Eaker, D., Karlsson, B., Arnberg, H., and Fryklund, L. (in preparation).
Fatt, P., and Katz, B., J. Physiol., 115, 320 (1951).
del Castillo, J., and Katz, B., J. Physiol., 124, 560 (1954).
Martin, A. R., Physiol. Rev., 66, 51 (1966).
Birks, R., Huxley, H. E., and Katz, B., J. Physiol., 150, 134 (1960).
Kühne, W., Z. Biol., 23, 1 (1887).
Eaker, D., and Porath, J., J., Japan J. Microbiol., 11, 355 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LESTER, H. Postsynaptic Action of Cobra Toxin at the Myoneural Junction. Nature 227, 727–728 (1970). https://doi.org/10.1038/227727a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/227727a0
- Springer Nature Limited
This article is cited by
-
Binding of3H-labelled cobra neurotoxin to cholinergic receptors in fast and slow mammalian muscles
Journal of Neural Transmission (1974)
-
Australian Tiger Snake Venom—an Inhibitor of Transmitter Release
Nature New Biology (1973)
-
Chemistry of some potent animal toxins
Experientia (1973)