Abstract
IT has been suggested1–4 that monosodium glutamate (MSG) is responsible for the “Chinese restaurant syndrome”—a burning sensation in the back of the neck spreading to the forearms and to the anterior thorax, accompanied by a feeling of infraorbital pressure, tightness and substernal discomfort. But no study of this phenomenon involved a double blind technique, or any other experimental condition which can be used to assess the significance of subjective reactions.
Similar content being viewed by others
References
Man-Kwdk, R. Ho, New Engl. J. Med., 278, 796 (1968).
Schaumburg, H. H., and Byck, R., New Engl. J. Med., 279, 105 (1968).
Abos, M., Leavitt, M. R., Marmorek, L., and Wolschina, S. B., New Engl. J. Med., 279, 105 (1968).
Schaumburg, H. H., Byck, R., Gerstl, G., and Mashman, J. H., Science, 163, 826 (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MORSELLI, P., GARATTINI, S. Monosodium Glutamate and the Chinese Restaurant Syndrome. Nature 227, 611–612 (1970). https://doi.org/10.1038/227611a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/227611a0
- Springer Nature Limited
This article is cited by
-
Unraveling the MSG-Headache Controversy: an Updated Literature Review
Current Pain and Headache Reports (2024)
-
Migraine and Diet: Updates in Understanding
Current Neurology and Neuroscience Reports (2022)
-
Does monosodium glutamate really cause headache? : a systematic review of human studies
The Journal of Headache and Pain (2016)
-
Sensitivity to food additives, vaso‐active amines and salicylates: a review of the evidence
Clinical and Translational Allergy (2015)
-
The effects of black garlic (Allium sativum L.) ethanol extract on the estimated total number of Purkinje cells and motor coordination of male adolescent Wistar rats treated with monosodium glutamate
Anatomical Science International (2015)