Abstract
THE discovery of sex-linked anaemia in the descendants of an irradiated mouse was followed by further evidence and the suggestion2 that there was a hereditary defect in intestinal iron absorption in these animals. Our studies on everted gut sacs in vitro provide the first direct evidence of a selective genetic defect in the second or serosal transfer step3 of the active transport mechanism for iron in the duodenum of the sex-linked anaemic (sla) mouse.
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References
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MANIS, J. Active Transport of Iron by Intestine: Selective Genetic Defect in the Mouse. Nature 227, 385–386 (1970). https://doi.org/10.1038/227385a0
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DOI: https://doi.org/10.1038/227385a0
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