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Inactivation of Angiotensin II Analogues by Isolated Perfused Rat Liver and Kidney

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Abstract

CHANGES in the activity of enzymes which destroy angiotensin may be concerned in the development of hypertension, but many relevant studies have involved tissue homogenates1–7 which may not reflect accurately the capacity of intact organs to remove circulating angiotensin. Intracellular enzymes, that normally have limited or no access to perfusing blood, are released when tissue extracts are prepared. Others8–11, however, recognizing this problem, investigated angiotensin inactivation by perfused organs in vivo, and demonstrated the dominant role of organ vascular beds in the inactivation of angiotensin in rats and dogs and the relative unimportance of circulating angiotensinases. A tentative explanation is that tissue enzymes are involved rather than storage of angiotensin at receptor sites (results of W. P. L., J. G. L. and J. W. Ryan, unpublished).

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References

  1. Dexter, L., Ann. Int. Med., 17, 447 (1942).

    Article  CAS  Google Scholar 

  2. Bing, J., Acta Path. Microbiol. Scand., 56, 385 (1962).

    Article  CAS  Google Scholar 

  3. Hickler, R. B., Lauler, D. P., and Thorn, G. W., J. Clin. Invest., 42, 635 (1963).

    Article  CAS  Google Scholar 

  4. Lagrue, G., and Meyer, P., Path. Biol., 11, 895 (1963).

    CAS  Google Scholar 

  5. Biron, P., Landesman, R., and Hunt, J. C., Nature, 204, 1096 (1964).

    Article  ADS  CAS  Google Scholar 

  6. Birbari, A. E., and Hickler, R. B., Circulation Suppl., Nos. 31–32, 2, 50 (1965).

    Google Scholar 

  7. Itskovitz, H. D., Dudrick, S. J., and Dyrda, I., Arch. Int. Med., 119, 241 (1967).

    Article  CAS  Google Scholar 

  8. Hodge, R. L., Ng, K. K. F., and Vane, J. R., Nature, 215, 138 (1967).

    Article  ADS  CAS  Google Scholar 

  9. Bakhle, Y. S., Reynard, A. M., and Vane, J. R., Nature, 222, 956 (1969).

    Article  ADS  CAS  Google Scholar 

  10. Biron, P., Meyer, P., and Panisset, J. C., Canad. J. Physiol. Pharmacol., 46, 175 (1968).

    Article  CAS  Google Scholar 

  11. Leary, W. P., and Ledingham, J. G., Nature, 222, 959 (1969).

    Article  ADS  CAS  Google Scholar 

  12. Leary, W. P., Ledingham, J. G., and Woods, H. F., Abst. Fourth Intern. Cong. on Nephrology, Stockholm, 1, 192 (1969).

    Google Scholar 

  13. Leary, W. P., and Ledingham, J. G., Clin. Sci., 38, 573 (1970).

    Article  CAS  Google Scholar 

  14. Leary, W. P., thesis (Univ. of Oxford, 1969).

  15. Khairallah, P. A., and Page, I. H., Biochem. Med., 1, 1 (1967).

    Article  CAS  Google Scholar 

  16. Regoli, D., Riniker, B., and Brunner, H., Biochem. Pharmacol., 12, 637 (1963).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of the Regius Professor of Medicine, and Metabolic Research Laboratory, Nuffield Department of Medicine, Oxford

    W. P. LEARY & J. G. LEDINGHAM

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  1. W. P. LEARY
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  2. J. G. LEDINGHAM
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LEARY, W., LEDINGHAM, J. Inactivation of Angiotensin II Analogues by Isolated Perfused Rat Liver and Kidney. Nature 227, 178–179 (1970). https://doi.org/10.1038/227178a0

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  • DOI: https://doi.org/10.1038/227178a0

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