Abstract
THE degree of malignancy of tumour cells may be related to the magnitude of the cell surface charge presented by exposed macromolecular groups of the enlarged muco-polysaccharide layers around tumour cells1, and it has also been suggested2 that this surface charge inhibits the recognition of tumour antigens by lymphocytes. Removal of excess mucopolysaccharide with neuraminidase restores fibroblast cells which are transformed by polyoma virus to normal3. Ehrlich ascites tumour cells, which have a large negative surface charge, provide a sensitive system for electrophoretic studies of some surface properties.
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REPACHOLI, M. Electrophoretic Mobility of Tumour Cells exposed to Ultrasound and Ionizing Radiation. Nature 227, 166–167 (1970). https://doi.org/10.1038/227166a0
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DOI: https://doi.org/10.1038/227166a0
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