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Accumulation of Chorio-retinotoxic Drugs in the Foetal Eye

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Abstract

USING whole body autoradiography1 we have found a selective accumulation and retention of certain drugs-in the eyes of mouse foetuses. These drugs are known to cause ocular damage in adult humans and experimental animals. The injury (toxic retinopathy), which is not seen in albino animals, has been related to the affinity of the drugs for the melanin structures of the eye2. The risk of foetal ocular damage appears to have been neglected in the past.

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Authors and Affiliations

  1. Department of Toxicology, University of Uppsala, Uppsala, Sweden

    S. ULLBERG, N. G. LINDQUIST & S. E. SJÖSTRAND

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  1. S. ULLBERG
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  2. N. G. LINDQUIST
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  3. S. E. SJÖSTRAND
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ULLBERG, S., LINDQUIST, N. & SJÖSTRAND, S. Accumulation of Chorio-retinotoxic Drugs in the Foetal Eye. Nature 227, 1257–1258 (1970). https://doi.org/10.1038/2271257a0

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  • DOI: https://doi.org/10.1038/2271257a0

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