Skip to main content
SpringerLink
Log in

In vitro Cytotoxic Activity of Thymus Cells sensitized to Alloantigens

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

THE thymus plays an important part in the development of certain immune reactions. Neonatally thymectomized mice showed an impaired antibody response to heterologous erythrocytes and serum proteins1. Recent studies, have demonstrated that collaboration between thymus-derived cells and bone marrow-derived cells was essential for mice to respond to sheep red blood cells (SRBC) by producing haemolysin-forming cells2–4. Thymus-derived cells, although undergoing mitosis in response to the antigenic stimulus5, did not produce antibody6, but influenced bone marrow-derived precursor cells to differentiate into antibody-producing cells4.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Miller, J. F. A. P., and Osoba, D., Physiol. Rev., 47, 437 (1967).

    Article  CAS  Google Scholar 

  2. Claman, H. N., Chaperon, E. A., and Triplett, R. F., Proc. Soc. Exp. Biol. Med., 122, 1167 (1966).

    Article  CAS  Google Scholar 

  3. Miller, J. F. A. P., and Mitchell, G. F., J. Exp. Med., 128, 801 (1968).

    Article  CAS  Google Scholar 

  4. Mitchell, G. F., and Miller, J. F. A. P., J. Exp. Med., 128, 821 (1968).

    Article  CAS  Google Scholar 

  5. Davies, A. J. S., Leuchars, E., Wallis, V., and Koller, P. C., Transplantation, 4, 438 (1966).

    Article  CAS  Google Scholar 

  6. Davies, A. J. S., Leuchars, E., Wallis, V., Marchant, R., and Elliott, E. V., Transplantation, 5, 222 (1967).

    Article  Google Scholar 

  7. Brunner, K. T., Mauel, J., Cerottini, J.-C., and Chapuis, B., Immunology, 14, 181 (1967).

    Google Scholar 

  8. Brunner, K. T., Mauel, J., Rudolf, H., and Chapuis, B., Immunology (in the press).

  9. Martin, W. J., J. Immunol., 103, 979 (1969).

    CAS  PubMed  Google Scholar 

  10. Billingham, R. E., Ann. NY Acad. Sci., 73, 782 (1958).

    Article  ADS  CAS  Google Scholar 

  11. Vos, O., de Vries, J., Collenteur, J. C., and van Bekkum, D. W., J. Nat. Cancer Inst., 23, 53 (1959).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Immunology, Swiss Institute for Experimental Cancer Research, CH-1011, Lausanne

    J.-C. CEROTTINI, A. A. NORDIN & K. T. BRUNNER

Authors
  1. J.-C. CEROTTINI
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. A. NORDIN
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. T. BRUNNER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

CEROTTINI, JC., NORDIN, A. & BRUNNER, K. In vitro Cytotoxic Activity of Thymus Cells sensitized to Alloantigens. Nature 227, 72–73 (1970). https://doi.org/10.1038/227072a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/227072a0

  • Springer Nature Limited

This article is cited by

Search

Navigation