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Specificity in Bacterial Protein Synthesis : Role of Initiation Factors and Ribosomal Subunits

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Abstract

Ribosomes from E. coli initiate synthesis in vitro of all three of the proteins coded by phage f2, but ribosomes from B. stearothermophilus initiate synthesis of only one. The specificity of initiation depends only on the source of the 30S subunits; the origin of the 50S sub-units and initiation factors has no effect.

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References

  1. Anderson, J., Dahlberg, J., Bretscher, M., Revel, M., and Clark, B., Nature, 216, 1072 (1967).

    Article  ADS  CAS  Google Scholar 

  2. Nomura, M., and Lowry, C. J., Proc. US Nat. Acad. Sci., 58, 946 (1967).

    Article  ADS  CAS  Google Scholar 

  3. Revel, M., Lelong, J. C., Brawerman, G., and Gros, F., Nature, 219, 1016 (1968).

    Article  ADS  CAS  Google Scholar 

  4. Iwasaki, K., Sabol, S., Wahba, A. J., and Ochoa, S., Arch. Biochem. Biophys., 1255, 42 (1968).

    Google Scholar 

  5. Greenshpan, H., and Revel, M., Nature, 224, 331 (1969).

    Article  ADS  CAS  Google Scholar 

  6. Clark, B., and Marcker, K., Nature, 211, 378 (1966).

    Article  ADS  CAS  Google Scholar 

  7. Ghosh, H. P., Soll, D., and Khorana, H. G., J. Mol. Biol., 25, 275 (1967).

    Article  CAS  Google Scholar 

  8. Lodish, H. F., Nature, 224, 867 (1969).

    Article  ADS  CAS  Google Scholar 

  9. Lodish, H. F., and Robertson, H. D., Cold Spring Harbor Symp. Quant. Biol., 34 (in the press).

  10. Lodish, H. F., and Robertson, H., J. Mol. Biol., 45, 9 (1969).

    Article  CAS  Google Scholar 

  11. Capecchi, M., J. Mol. Biol., 21, 173 (1966).

    Article  CAS  Google Scholar 

  12. Vinuela, E., Salas, M., and Ochoa, S., Proc. US Nat. Acad. Sci., 57, 729 (1967).

    Article  ADS  CAS  Google Scholar 

  13. Steitz, J. A., Nature, 224, 957 (1970).

    Article  ADS  Google Scholar 

  14. Brawerman, G., Revel, M., Salser, W., and Gros, F., Nature, 223, 957 (1969).

    Article  ADS  CAS  Google Scholar 

  15. Revel, M., Greenshpan, H., and Herzberg, M. (in the press).

  16. Lodish, H. F., Nature, 220, 345 (1968).

    Article  ADS  CAS  Google Scholar 

  17. Lodish, H. F., Biochem. Biophys. Res. Commun., 37, 127 (1969).

    Article  CAS  Google Scholar 

  18. Lodish, H. F., J. Mol. Biol. (in the press).

  19. Kolakofsky, D., Nature, 220, 244 (1968).

    Article  ADS  CAS  Google Scholar 

  20. Guthrie, C., and Nomura, M., Nature, 219, 232 (1968).

    Article  ADS  CAS  Google Scholar 

  21. Hindley, J., and Staples, D. H., Nature, 224, 964 (1969).

    Article  ADS  CAS  Google Scholar 

  22. Adams, J. M., Jeppesen, P. G. N., Sanger, F., and Barrell, B., Nature, 223 1009 (1969).

    Article  ADS  CAS  Google Scholar 

  23. Nichols, J. N., Nature, 225, 147 (1970).

    Article  ADS  CAS  Google Scholar 

  24. Revel, M., Herzberg, M., and Greenshpan, H., Cold Spring Harbor Symp. Quant. Biol., 34 (in the press).

  25. Lodish, H. F., J. Mol. Biol., 32, 681 (1968).

    Article  CAS  Google Scholar 

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LODISH, H. Specificity in Bacterial Protein Synthesis : Role of Initiation Factors and Ribosomal Subunits. Nature 226, 705–707 (1970). https://doi.org/10.1038/226705a0

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