Skip to main content
SpringerLink
Log in

Role of Thymus-derived Lymphocytes in the Secondary Humoral Immune Response in Mice

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

THERE is now good evidence that the theta (θ) isoantigen of mice1 is carried only by those peripheral lymphocytes which are thymus-derived2–4, so that anti-θ antiserum should be useful in elucidating the role of these cells in immunity. In experiments reported here, anti-θ has been used in vitro in an adoptive transfer system5 to study the function of thymus-derived lymphocytes in the secondary humoral immune response to hapten–protein conjugates, particularly in terms of cellular cooperation and carrier effects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Reif, A. E., and Allen, J. M., J. Exp. Med., 120, 413 (1964).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Schlesinger, M., and Yron, I., Science, 164, 1412 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Raff, M. C., Nature, 224, 378 (1969).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Raff, M. C., and Wortis, H. H., Immunology (in the press).

  5. Mäkelä, O., and Mitchison, N. A., Immunology, 8, 549 (1965).

    PubMed  PubMed Central  Google Scholar 

  6. Brownstone, A., Mitchison, N. A., and Pitt-Rivers, R., Immunology, 10, 465 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Brownstone, A., Mitchison, N. A., and Pitt-Rivers, R., Immunology, 10, 481 (1966).

    CAS  PubMed Central  Google Scholar 

  8. Mitchison, N. A., Proc. Roy. Soc., B, 161, 275 (1964).

    Article  ADS  CAS  Google Scholar 

  9. Mitchison, N. A., in Differentiation and Immunology (edit. by Warren, K. B.), 29 (Academic Press, New York, 1968).

    Book  Google Scholar 

  10. Mitchison, N. A., Rajewsky, K., and Taylor, R. B., in Symp. Developmental Aspects of Antibody Formation and Structure, Prague (in the press).

  11. Ovary, Z., and Benacerraf, B., Proc. Soc. Exp. Biol. NY, 114, 72 (1963).

    Article  CAS  Google Scholar 

  12. Rajewsky, K., Schirrmacher, V., Nase, S., and Jerne, N. K., J. Exp. Med., 129, 1131 (1969).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Taylor, R. B., Transplant. Rev., 1, 43 (1969).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Institute for Medical Research, Mill Hill, London, NW7

    MARTIN C. RAFF

Authors
  1. MARTIN C. RAFF
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

RAFF, M. Role of Thymus-derived Lymphocytes in the Secondary Humoral Immune Response in Mice. Nature 226, 1257–1258 (1970). https://doi.org/10.1038/2261257a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2261257a0

  • Springer Nature Limited

This article is cited by

Search

Navigation