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Anti-θ Antibodies for detecting Thymus-dependent Lymphocytes in the Immune Response of Mice to SRBC

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Abstract

MOUSE thymus cells possess a high concentration of the theta (θ)1 and Ly2 antigens. Several approaches have demonstrated that the sensitivity of peripheral muriiie lymphocytes to the cytotoxic effect of θ and Ly antibodies is a thymus-dependent property. The population of cells sensitive to the cytotoxic effect of θ antibodies disappears from lymph nodes3 and spleen4 after neonatal thymectomy. Similarly, following neonatal thymectomy, the population of cells sensitive to Ly antibodies disappears from lymph nodes (unpublished results of M. S. and Yron). Following administration of heterologous anti-lymphocyte serum, a procedure resulting in elimination of thymus-dependent lymphocytes5,6, cells sensitive to θ antibodies disappear transiently from the lymph nodes7 and spleen4.

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  1. Division of Immunology, Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina

    MICHAEL SCHLESINGER

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  1. MICHAEL SCHLESINGER
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SCHLESINGER, M. Anti-θ Antibodies for detecting Thymus-dependent Lymphocytes in the Immune Response of Mice to SRBC. Nature 226, 1254–1256 (1970). https://doi.org/10.1038/2261254a0

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  • DOI: https://doi.org/10.1038/2261254a0

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