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Anti-Nucleic Acid Specificities of Mouse Myeloma Immunoglobulins

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Abstract

Three mouse myeloma immunoglobulins were shown to have antibody specificities for DNA. Two of these proteins bound denatured DNA and RNA in preference to double stranded DNA; the third was unable to distinguish them.

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References

  1. Schubert, D., Jobe, A., and Cohn, M., Nature, 220, 882 (1968).

    Article  CAS  ADS  Google Scholar 

  2. Jones, O. W., and Berg, P., J. Mol. Biol., 22, 199 (1966).

    Article  CAS  Google Scholar 

  3. Riggs, A., Bourgeois, S., Newby, K., and Cohn, M., J. Mol. Biol., 34, 365 (1968).

    Article  CAS  Google Scholar 

  4. Pauling, L., Pressman, D., and Grossberg, A., J. Amer. Chem. Soc., 66, 784 (1944).

    Article  CAS  Google Scholar 

  5. Potter, M., in Methods in Cancer Research (edit. by Busch, H.), 2, 105 (Academic Press, New York, 1967).

    Google Scholar 

  6. Cohn, M., in Ciba Symposium on Control Processes in Multicellular Organisms (edit. by Wolstenholme, G. E. W.), 52 (Little Brown, Boston, 1969).

    Google Scholar 

  7. Cohn, M., Cold Spring Harbor Symp. Quant. Biol., 32, 211 (1967).

    Article  CAS  Google Scholar 

  8. Seligmann, M., and Arana, R., in Nucleic Acids in Immunology (edit. by Plescia, O. J., and Braun, W.), 98 (Springer, New York, 1968).

    Book  Google Scholar 

  9. Estrada-Parra, S., and Olguin-Palacios, E., in Nucleic Acids in Immunology (edit. by Plescia, O. J., and Braun, W.), 88 (Springer, New York, 1968).

    Book  Google Scholar 

  10. Eisen, H. N., Simms, E. S., and Potter, M., Biochemistry, 7, 4126 (1968).

    Article  CAS  Google Scholar 

  11. Hannestad, K., Clin. Exp. Immunol., 4, 555 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Karush, F., Ann. NY Acad. Sci. (in the press).

  13. Talmage, D. W., Science, 129, 1643 (1959).

    Article  CAS  ADS  Google Scholar 

  14. Singer, S. J., in The Proteins (edit. by Neurath, H.), 3, 269 (Academic Press, New York, 1965).

    Google Scholar 

  15. Landsteiner, K., The Specificity of Serological Reactions (Harvard University Press, Cambridge, 1945).

    Google Scholar 

  16. Levitzki, A., and Koshland, D. E., Proc. US Nat. Acad. Sci., 62, 1121 (1969).

    Article  CAS  ADS  Google Scholar 

  17. Ashman, R. F., and Metzger, H., J. Biol. Chem., 244, 3405 (1969).

    CAS  PubMed  Google Scholar 

  18. Mitchison, N. A., in Differentiation and Immunology (edit. by Warren, K. B.), 29 (Academic Press, New York, 1968).

    Book  Google Scholar 

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Authors and Affiliations

  1. Salk Institute for Biological Studies, San Diego, California

    DAVID SCHUBERT, ANN ROMAN & MELVIN COHN

Authors
  1. DAVID SCHUBERT
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  2. ANN ROMAN
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  3. MELVIN COHN
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SCHUBERT, D., ROMAN, A. & COHN, M. Anti-Nucleic Acid Specificities of Mouse Myeloma Immunoglobulins. Nature 225, 154–158 (1970). https://doi.org/10.1038/225154a0

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  • DOI: https://doi.org/10.1038/225154a0

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