Abstract
In the earliest stages of the development of mouse embryos, RNA synthesis can be blocked without inhibition of protein synthesis; but stopping protein synthesis depresses RNA synthesis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Thomson, J. L., and Biggers, J. D., Exp. Cell Res., 41, 411 (1966).
Mintz, B., J. Exp. Zool., 157, 85 (1964).
Skalko, R. G., and Morse, J. M. D., Teratology, 2, 47 (1969).
Silagi, S., Exp. Cell Res., 32, 149 (1963).
Edwards, R. G., and Gates, A. H., J. Endocrinol., 18, 292 (1959).
Brinster, R. L., Exp. Cell Res., 32, 205 (1963).
Schmidt, G., and Thannhauser, S., J. Biol. Chem., 161, 83 (1945).
Woodland, H. R., and Graham, C. F., Nature, 22l, 327 (1969).
Ellem, K. A. O., and Gwatkin, R. B. L., Develop. Biol., 18, 311 (1968).
Hillman, N. W., and Tasca, R. J., Amer. J. Anat. (in the press).
Perry, R. P., Exp. Cell Res., 29, 400 (1963).
Hillman, N. W., and Tasca, R. J., Proc. Twelfth Intern. Cong. Genetics, Tokyo, Abstr. 7.5.1 (1968).
Jackson, L. G., and Studzinski, G. P., Exp. Cell Res., 52, 408 (1968).
Monesi, V., and Salfi, V., Exp. Cell Res., 46, 632 (1967).
Fautrez-Firlefyn, N., and Fautrez, J., Intern. Rev. Cytol., 22, 171 (1967).
Busch, H., Histones and Other Nuclear Proteins (Academic Press, New York, 1965).
Chalkley, G. R., and Maurer, H. R., Proc. US Nat. Acad. Sci., 54, 498 (1965).
Paul, J., and Gilmour, R. S., J. Mol. Biol., 34, 305 (1968).
Mitchinson, J. M., and Cummins, J. E., J. Cell Sci., 1, 35 (1966).
Pardee, A. B., Nat. Cancer Inst. Monograph., 27, 249 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TASCA, R., HILLMAN, N. Effects of Actinomycin D and Cycloheximide on RNA and Protein Synthesis in Cleavage Stage Mouse Embryos. Nature 225, 1022–1025 (1970). https://doi.org/10.1038/2251022a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/2251022a0
- Springer Nature Limited
This article is cited by
-
Apicobasal RNA asymmetries regulate cell fate in the early mouse embryo
Nature Communications (2023)
-
In vitro development of one-cell embryos from outbred mice: Influence of culture medium composition
In Vitro Cellular & Developmental Biology (1990)
-
Visualization of transcription in early mouse embryos
Chromosoma (1979)
-
RNA synthesis in fully-grown mouse oocytes
Nature (1976)
-
Incorporation of arginine-3H into chromatin of mouse eggs shortly after sperm penetration
Histochemistry (1975)