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Drug-induced Relief of the Tremor in Monkeys with Mesencephalic Lesions

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Abstract

MODEL syndromes of extrapyramidal dysfunction have been induced in monkeys by introduction of unilateral lesions into the ventromedial area of the brain stem1. In such cases the destruction of the pars compacta of the substantia nigra is associated with low concentrations of dopamine and serotonin in the corresponding basal ganglia1. The reduction of the biogenic amines in the striatum is concomitant with an impairment in the storage of dopamine and serotonin (5-HT) and with a decrease in tyrosine hydroxylase and DOPA decarboxylase activity2–4. Thus the ventromedial tegmental lesion affects the storage and biosynthesis of dopamine and 5-HT in the ipsilateral striatum.

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Authors and Affiliations

  1. Departments of Psychiatry and Neurosurgery, New York University Medical Center, New York, NY, 10016

    M. GOLDSTEIN, A. F. BATTISTA, S. NAKATANI & B. ANAGNOSTE

Authors
  1. M. GOLDSTEIN
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  2. A. F. BATTISTA
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  3. S. NAKATANI
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  4. B. ANAGNOSTE
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GOLDSTEIN, M., BATTISTA, A., NAKATANI, S. et al. Drug-induced Relief of the Tremor in Monkeys with Mesencephalic Lesions. Nature 224, 382–384 (1969). https://doi.org/10.1038/224382a0

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  • DOI: https://doi.org/10.1038/224382a0

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