Abstract
Using a rapid one-step method, circular DNA has been isolated from a strain of E. coli harbouring the R-factor R-1 and shown to contain at least two separate classes of covalently closed molecules. Evidence is presented for the stable existence of circular R-factor in E. coli.
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COHEN, S., MILLER, C. Multiple Molecular Species of Circular R-factor DNA isolated from Escherichia coll. Nature 224, 1273–1277 (1969). https://doi.org/10.1038/2241273a0
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DOI: https://doi.org/10.1038/2241273a0
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