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Structural Requirements of Selective Inhibition of Enteroviruses by 2-(α-Hydroxybenzyl)-benzimidazole and Related Compounds

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Abstract

A survey of the antiviral activity of forty-one derivatives of 2-(α-hydroxybenzyl)-benzimidazole (HBB) pinpoints the structural features of the HBB molecule essential for selective inhibition of viral multiplication.

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Author notes

  1. H. J. EGGERS

    Present address: Institut für Virologie, Giessen, Germany

  2. R. BABLANIAN

    Present address: State University of New York Downstate Medical Center, Brooklyn, New York

  3. K. FOLKERS

    Present address: Institute for Biomedical Research, University of Texas, Austin, Texas

Authors and Affiliations

  1. The Rockefeller University New York, New York

    I. TAMM, H. J. EGGERS & R. BABLANIAN

  2. Merck Sharp and Dohme Research Laboratories, Division of Merck and Co. Inc., Rahway, New Jersey

    A. F. WAGNER & K. FOLKERS

Authors
  1. I. TAMM
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  2. H. J. EGGERS
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  3. R. BABLANIAN
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  4. A. F. WAGNER
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  5. K. FOLKERS
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TAMM, I., EGGERS, H., BABLANIAN, R. et al. Structural Requirements of Selective Inhibition of Enteroviruses by 2-(α-Hydroxybenzyl)-benzimidazole and Related Compounds. Nature 223, 785–788 (1969). https://doi.org/10.1038/223785a0

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  • DOI: https://doi.org/10.1038/223785a0

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