Abstract
THE red cell phosphoglucomutase electrophoretic pattern depends on two independent autosomal loci, PGM1 and PGM2 (refs. 1 and 2). The first one is polymorphic in all the races3, the second only among Negroes3,4. A number of rare variants of both the PGM1 and PGM2 genes have also been described3. The genetics of phosphoglucomutase has been comprehensively reviewed5. A set of at least two electrophoretic bands are associated with each PGM1 or PGM2 allele.
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References
Spencer, N., Hopkinson, D. A., and Harris, H., Nature, 204, 742 (1964).
Hopkinson, D. A., and Harris, H., Nature, 208, 410 (1965).
Hopkinson, D. A., and Harris, H., Ann. Hum. Genet., 30, 167 (1966).
Santachiara, A. S., and Modiano, G., Amer. J. Hum. Genet. (in the press).
Giblett, E., Genetic Markers in Human Blood (Blackwell Scientific Publications, in the press).
Huisman, T. H. J., Martis, E. A., and Dozy, A., J. Lab. Clin. Med., 52, 312 (1958).
Wroblesky, F., and La Due, J. S., Proc. Soc. Exp. Biol. NY, 90, 210 (1955).
Markert, C. L., and Appella, E., Ann. NY Acad. Sci., 94, 681 (1961).
Kegeles, G., and Gutter, F. J., J. Amer. Chem. Soc., 73, 3770 (1951).
Braunitzer, G., Hilse, K., Rudloff, V., and Hilschmann, N., in Adv. Prot. Chem. (edit. by Anfinsen, jun., C. B., Anson, M. L., Edsall, J. T., and Richards, F. M.), 19, 21 (Academic Press, New York, 1964).
Martin, R. G., and Ames, B. N., J. Biol. Chem., 236, 1372 (1961).
Joshi, J. G., Hashimoto, T., Hanabusa, K., Dougherty, H. W., and Handler, P., in Evolving Genes and Proteins (edit. by Bryson, V., and Vogel. J.), 209 (Academic Press, New York, 1965).
Monn, E., Bull. Europ. Soc. Hum. Genet., 1, 89 (1969).
Harris, H., Hopkinson, D. A., Luffman, Jill, E., and Rapley, Sandra, in Symp. Hereditary Disorders of Erythrocyte Metabolism (edit. by Beutler, E.), 1 (Grune and Stratton, 1968).
Joshi, J. G., Hooper, J., Kuwaki, T., Sakurada, T., Swanson, J. R., and Handler, P., Proc. US Nat. Acad. Sci., 57, 1482 (1967).
Epstein, C. J., and Schechter, A. N., Ann. NY Acad. Sci., 151, 85 (1968).
Brewer, G. J., Amer. J. Hum. Genet., 19, 674 (1967).
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SANTACHIARA, A., MODIANO, G. Ultracentrifuge Studies of Red Cell Phosphoglucomutase. Nature 223, 625–626 (1969). https://doi.org/10.1038/223625a0
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DOI: https://doi.org/10.1038/223625a0
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