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Diminished Responsiveness to Thyroid Hormone in Riboflavin-deficient Rats

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Abstract

THE hepatic activity of mitochondrial α-glycerophosphate dehydrogenase can be up to 100-fold greater in hyperthyroid rats than thyroidectomized rats1. Both the thyroid hormones, thyroxine or triiodothyronine, or their analogues, enhance enzyme activity and enhancement is blocked by simultaneous administration of actinomycin D and/or puromycin2,3. The enhancement has been suggested as a test for thyroid function4. Here we report that both the basal activity of the enzyme and the maximal activity induced by triiodothyronine are dependent upon adequate dietary intake of riboflavin.

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Authors and Affiliations

  1. Department of Medicine and Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New York, New York

    RICHARD S. RIVLIN & GAIL WOLF

Authors
  1. RICHARD S. RIVLIN
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  2. GAIL WOLF
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RIVLIN, R., WOLF, G. Diminished Responsiveness to Thyroid Hormone in Riboflavin-deficient Rats. Nature 223, 516–517 (1969). https://doi.org/10.1038/223516a0

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  • DOI: https://doi.org/10.1038/223516a0

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