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Induction of Immunological Tolerance by Porcine Liver Allografts

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Abstract

Liver allografting experiments with pigs show that animals given no immunosuppression will survive for prolonged periods with orthotopic liver transplants. Similar animals can reject skin, kidneys and hearts rapidly. Orthotopic and accessory heterotopic liver allografts protect preferentially from rejection grafts of donor specific skin, kidney and possibly heart. Injected soluble liver antigen may also protect donor specific tissue from rejection. It is suggested that allogeneic liver can induce immunological tolerance in immunologically mature pigs.

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Authors and Affiliations

  1. Department of Surgery, University of Cambridge,

    R. Y. CALNE, R. A. SELLS, J. R. PENA & D. R. DAVIS

  2. Department of Pathology, University of Cambridge,

    P. R. MILLARD & B. M. HERBERTSON

  3. The Department of Experimental Pathology, A. R. C. Institute of Animal Physiology, Babraham

    R. M. BINNS

  4. Searle Research Laboratories, High Wycombe

    D. A. L. DAVIES

Authors
  1. R. Y. CALNE
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  2. R. A. SELLS
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  3. J. R. PENA
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  4. D. R. DAVIS
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  5. P. R. MILLARD
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  6. B. M. HERBERTSON
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  7. R. M. BINNS
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  8. D. A. L. DAVIES
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CALNE, R., SELLS, R., PENA, J. et al. Induction of Immunological Tolerance by Porcine Liver Allografts. Nature 223, 472–476 (1969). https://doi.org/10.1038/223472a0

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  • DOI: https://doi.org/10.1038/223472a0

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