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Role of Haemichromes in the Formation of Inclusion Bodies in Haemoglobin H Disease

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Abstract

In haemoglobin H disease, excess β chains form haemoglobin tetramers which are unstable and which readily precipitate to form inclusion bodies. Electron paramagnetic resonance and spectroscopic evidence indicates that the precipitated haemoglobin is in the form of a haemichrome.

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Author notes

  1. E. A. RACHMILEWITZ: On leave from the Department of Medicine, Hebrew University–Hadassah Medical School, Jerusalem, Israel.

Authors and Affiliations

  1. Departments of Physiology and Medicine,

    E. A. RACHMILEWITZ

  2. Departments of Pharmacology and Molecular Biology,

    J. PEISACH

  3. Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, 10461

    T. B. BRADLEY jun.

  4. Bell Telephone Laboratories, Murray Hill, New Jersey, 07974

    W. E. BLUMBERG

Authors
  1. E. A. RACHMILEWITZ
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  2. J. PEISACH
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  3. T. B. BRADLEY jun.
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  4. W. E. BLUMBERG
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RACHMILEWITZ, E., PEISACH, J., BRADLEY, T. et al. Role of Haemichromes in the Formation of Inclusion Bodies in Haemoglobin H Disease. Nature 222, 248–250 (1969). https://doi.org/10.1038/222248a0

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  • DOI: https://doi.org/10.1038/222248a0

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