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Antitumoral Activity of the Fern Cibotium schiedei

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Abstract

THE use of plant preparations for treating cancer, first mentioned in the Ebers papyrus of 1500 BC1, has long been widespread in spite of the general ineffectiveness of such remedies. At present, several compounds of plant origin are known to have demonstrable oncolytic activity. These include colchicine2, the vinca alkaloids3, podophyllotoxin4, the cucurbitacins5, lapachol6 and the steroid tumour inhibitors from certain of the Solanaceae7; all these are derived from angiosperms. The only antitumoral agent reported in lower vascular plants is calagualine, a saponine isolated from the fern Polypodium leucotomos8. A note by Maruzzella9 relating to the antibiotic activity of methanolic extracts of several ferns prompted us to test Cibotium schiedei Schlect and Cham. as a possible source of tumour inhibitors. This tree fern, of the family Dicksoniaceae, is a native of the Vera Cruz province of Mexico, but is quite widely cultivated as a house plant.

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References

  1. Ebbell, B., The Papyrus Ebers. The Greatest Egyptian Medical Document (Oxford University Press, London, 1937).

    Google Scholar 

  2. Eigsti, O. J., and Dustin, jun., P., Colchicine in Agriculture, Medicine, Biology and Chemistry (Iowa State College Press, Ames, 1955).

    Google Scholar 

  3. Johnson, I. S., Armstrong, J. G., Gorman, M., and Burnett, J. P., Cancer Res., 23, 1390 (1963).

    CAS  PubMed  Google Scholar 

  4. Kelly, M. G., and Hartwell, J. L., J. Nat. Cancer Inst., 14, 967 (1953).

    Google Scholar 

  5. Gitter, S., Gallily, R., Shohat, B., and Lavie, D., Cancer Res., 21, 516 (1961).

    CAS  PubMed  Google Scholar 

  6. Rao, K. V., McBride, T. J., and Oleson, J. J., Cancer Res., 28, 1952 (1968).

    CAS  Google Scholar 

  7. Kupchan, S. M., Barboutis, S. J., Knox, J. R., and Lau Cam, C. A., Science, 150, 1827 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Horvath, A., Alvarado, F., Szöcs, J., De Alvarado, Z. N., and Padilla, G., Nature, 214, 1256 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Maruzzella, J. C., Nature, 191, 518 (1961).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Creasey, W. A., Biochem. Pharmacol., 18, 227 (1969).

    Article  CAS  PubMed  Google Scholar 

  11. Creasey, W. A., and Markiw, M. E., Biochim. Biophys. Acta, 87, 601 (1964).

    CAS  PubMed  Google Scholar 

  12. Mokrasch, L. C., and McGilvery, R. W., J. Biol. Chem., 221, 909 (1956).

    CAS  PubMed  Google Scholar 

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  1. Departments of Medicine and Pharmacology, Yale University School of Medicine, New Haven, Connecticut, 06510

    WILLIAM A. CREASEY

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  1. WILLIAM A. CREASEY
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CREASEY, W. Antitumoral Activity of the Fern Cibotium schiedei. Nature 222, 1281–1282 (1969). https://doi.org/10.1038/2221281a0

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  • DOI: https://doi.org/10.1038/2221281a0

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