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In vitro Production of Angiotensin I by Renal Glomeruli

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Abstract

To investigate the mechanism of the release of renin we have isolated the juxtaglomerular apparatus and recorded changes in renin secretion in response to various stimuli. To separate and concentrate the juxtaglomerular apparatus we isolated glomeruli and incubated them in a defined medium. The glomeruli were then tested for pressor activity. Clearly, if such a preparation had a characteristic secretion pattern for renin, then we would have a concentration of viable juxtaglomerular apparatus ready for in vitro studies. This communication summarizes our results and the unexpected finding that glomeruli produce a pressor substance distinct from renin.

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References

  1. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., Biol. Chem., 193, 265 (1961).

    Google Scholar 

  2. Arakawa, K., and Nakamura, M., Circulation Res., 21 (Suppl. II), 101 (1968).

    Google Scholar 

  3. Bumpus, F. M., Trans. NY Acad. Sci., 27, 445 (1965).

    Article  CAS  Google Scholar 

  4. Skeggs, L. T., Kahn, J. R., and Shumway, N. P., J. Exp. Med., 103, 295 (1956).

    Article  CAS  Google Scholar 

  5. Martin, E., Scheideger, J. J., Grabar, P., and Williams, C. A., Bull. Schwiz. Akad. Med. Wiss., 10, 193 (1954).

    CAS  Google Scholar 

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Authors and Affiliations

  1. Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina

    SAMUEL FINKIELMAN & VICTOR E. NAHMOD

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  1. SAMUEL FINKIELMAN
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  2. VICTOR E. NAHMOD
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FINKIELMAN, S., NAHMOD, V. In vitro Production of Angiotensin I by Renal Glomeruli. Nature 222, 1186–1188 (1969). https://doi.org/10.1038/2221186a0

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  • DOI: https://doi.org/10.1038/2221186a0

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