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Protection by some Carbamates against the Delayed Neurotoxic Effects of Di-isopropyl Phosphorofluoridate

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Abstract

ADMINISTRATION of a single dose of many organophosphorus esters to hens and other species produces a delayed neurotoxic effect characterized by a flaccid paralysis of hind limbs developing after a symptomless period of 8–14 days (for a review see ref. 1). We have studied the effect produced by di-isopropyl phosphorofluoridate (DFP) because it is a potent neurotoxic compound and does not need to be metabolized to produce the active agent.

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References

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Author notes

  1. R. LAUWERYS: Visiting worker from the University of Louvain, Belgium.

Authors and Affiliations

  1. Biochemical Mechanisms Section, MRC Toxicology Research Unit, Woodmansterne Road, Carshalton, Surrey

    M. K. JOHNSON & R. LAUWERYS

Authors
  1. M. K. JOHNSON
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  2. R. LAUWERYS
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JOHNSON, M., LAUWERYS, R. Protection by some Carbamates against the Delayed Neurotoxic Effects of Di-isopropyl Phosphorofluoridate. Nature 222, 1066–1067 (1969). https://doi.org/10.1038/2221066a0

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  • DOI: https://doi.org/10.1038/2221066a0

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