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Stochastic Model for the Production of Antibody-forming Cells

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Abstract

FOR some time it has been thought that the generation of antibody-forming cells (AFC) may involve an interaction between cell types1–3. We present here a stochastic model, based on a two-cell interaction system, for the production of AFC. The assumptions on which the model is based have chiefly come from an interpretation of two types of experimental data, each of which can yield information concerning the number of cells involved. The first is limiting dilution analysis, which is based on the Poisson probability distribution. The second is dose–response analysis, showing the relationship between lymphoid cell dose and the number of AFC generated. These types of experiments involve either the transfer of lymphoid cells to irradiated, compatible recipients or the growth of lymphoid cells in diffusion chamber cultures.

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Authors and Affiliations

  1. Biology Division and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee

    D. L. GROVES, W. E. LEVER & T. MAKINODAN

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  1. D. L. GROVES
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  2. W. E. LEVER
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  3. T. MAKINODAN
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GROVES, D., LEVER, W. & MAKINODAN, T. Stochastic Model for the Production of Antibody-forming Cells. Nature 222, 95–97 (1969). https://doi.org/10.1038/222095a0

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  • DOI: https://doi.org/10.1038/222095a0

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