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Inhibition of Gastric Acid Secretion in vitro by Prostaglandin E1

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Abstract

ADMINISTRATION of gastrin or histamine leads to the secretion of hydrochloric acid by the vertebrate stomach. The details of this process are so far largely unknown. The effects of a variety of hormones in other tissues are mediated by the intracellular level of cyclic AMP (adenosine 3′,5′-monophosphate)1. In several such examples the naturally occurring unsaturated fatty acid, prostaglandin E1 (PGE1), blocks hormonal action. Thus inhibition of epinephrine-induced lipolysis2 and vasopressin-induced changes in osmotic permeability3 by PGE1 have been attributed to interference with the accumulation of cyclic AMP induced by the respective hormone in the target organ or tissue.

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References

  1. Sutherland, E. W., Robison, G. A., and Butcher, R. W., Circulation, 37, 279 (1968).

    Article  CAS  Google Scholar 

  2. Butcher, R. W., and Baird, C. E., J. Biol. Chem., 243, 1713 (1968).

    PubMed  CAS  Google Scholar 

  3. Orloff, J., Handler, J. S., and Bergstrom, S., Nature, 205, 398 (1965).

    Article  ADS  Google Scholar 

  4. Robert, A., Nezamis, J. E., and Phillips, J. P., Amer. J. Dig. Dis., 12, 1073 (1967).

    Article  CAS  PubMed  Google Scholar 

  5. Ramwell, P. W., and Shaw, J. E., J. Physiol., 195, 34P (1968).

    PubMed  CAS  Google Scholar 

  6. Carlson, L. A., and Oro, L., Acta Physiol. Scand., 67, 89 (1966).

    Article  CAS  PubMed  Google Scholar 

  7. Bennett, A., Murray, J. G., and Wyllie, J. H., Brit. J. Pharmacol. Chemother., 32, 339 (1968).

    Article  CAS  Google Scholar 

  8. Berti, F., Kabir, N. M., Lentati, R., Usardi, M. M., Mantegazza, P., and Paoletti, R., Prog. Biochem. Pharmacol., 3, 110 (1967).

    CAS  Google Scholar 

  9. Durbin, R. P., J. Gen. Physiol., 47, 735 (1964).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Kasbekar, D. K., Proc. Soc. Exp. Biol. and Med., 125, 267 (1967).

    Article  CAS  Google Scholar 

  11. Harris, J. B., and Alonso, D., Fed. Proc., 24, 1368 (1965).

    PubMed  CAS  Google Scholar 

  12. Harris, J. B., Gastroenterology, 52, 1135 (1967).

    Google Scholar 

  13. Bergstrom, S., Science, 157, 382 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. Steinberg, D., Ann. NY Acad. Sci., 139, 897 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Cardiovascular Research Institute, and Department of Surgery, University of California Medical Center, San Francisco, California

    L. WAY & R. P. DURBIN

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  1. L. WAY
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  2. R. P. DURBIN
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WAY, L., DURBIN, R. Inhibition of Gastric Acid Secretion in vitro by Prostaglandin E1. Nature 221, 874–875 (1969). https://doi.org/10.1038/221874a0

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  • DOI: https://doi.org/10.1038/221874a0

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