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Partial Structure of the Peptide Antibiotic Stendomycin as determined by Mass Spectrometry

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Abstract

THE antifungal antibiotic stendomycin has been isolated1 from Streptomyces antimycoticus and chemical studies have revealed that this is not a homogeneous compound but a family of closely related antibiotics which differ from each other in their fatty acid constituents2–4. On the basis of chemical evidence, structure I has recently been suggested by Bodanszky et al.5 for the chief stendomycin component. The fatty acid constituent of this tetradecapeptide lactone was further characterized as isomyristic acid2, and structure II was ascribed5 to the basic amino-acid residue B.

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Authors and Affiliations

  1. Institut de Chimie des Substances Naturelles, CNRS, 91, Gif-sur-Yvette

    D. W. THOMAS & E. LEDERER

  2. Department of Chemistry, Case Western Reserve University, Cleveland, Ohio

    M. BODANSZKY, J. IZDEBSKI & I. MURAMATSU

Authors
  1. D. W. THOMAS
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  2. E. LEDERER
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  3. M. BODANSZKY
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  4. J. IZDEBSKI
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  5. I. MURAMATSU
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THOMAS, D., LEDERER, E., BODANSZKY, M. et al. Partial Structure of the Peptide Antibiotic Stendomycin as determined by Mass Spectrometry. Nature 220, 580–582 (1968). https://doi.org/10.1038/220580a0

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  • DOI: https://doi.org/10.1038/220580a0

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