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Production of Complement by Spleen Cells in vitro and its Possible Role in an Allograft Rejection Model

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Abstract

IT is generally agreed that the rejection of a primary allograft is initiated by contact between specifically sensitized lymphoid cells and graft tissue. To study the exact mechanism of such injury1–4 the experimental model of Rosenau and Moon5 has been used. This represents an in vitro allograft rejection of L strain fibroblasts by specifically sensitized spleen cells. We have reported6 that the sensitized spleen cells have an altered surface charge which might explain the tendency of such sensitized cells to aggregate about the target cells; this observation applies to several other similar experimental models7–9.

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Authors and Affiliations

  1. Department of Pathology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada

    H. E. TAYLOR & C. F. A. CULLING

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  1. H. E. TAYLOR
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  2. C. F. A. CULLING
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TAYLOR, H., CULLING, C. Production of Complement by Spleen Cells in vitro and its Possible Role in an Allograft Rejection Model. Nature 220, 506–507 (1968). https://doi.org/10.1038/220506a0

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