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Meiotic Chromosome Alterations produced by Progesterone

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Abstract

ADMINISTRATION of progestins has been shown to suppress spermatogenesis in intact animals and humans, but the mechanisms involved have not been fully defined1–3. Using an adaptation of the method of Eik-Nes4 we have shown that perfusion of the canine testis with progesterone causes alterations in the meiotic chromosomes—chiefly sticky degeneration and improper spreading with clumping of the chromosomes.

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Authors and Affiliations

  1. Department of Medicine, Section of Endocrinology, University of Tennessee College of Medicine, Memphis, Tennessee

    DOROTHY L. WILLIAMS, JOHN W. RUNYAN & A. AINSWORTH HAGEN

Authors
  1. DOROTHY L. WILLIAMS
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  2. JOHN W. RUNYAN
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  3. A. AINSWORTH HAGEN
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WILLIAMS, D., RUNYAN, J. & HAGEN, A. Meiotic Chromosome Alterations produced by Progesterone. Nature 220, 1145–1147 (1968). https://doi.org/10.1038/2201145a0

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  • DOI: https://doi.org/10.1038/2201145a0

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