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Direct Translation of a Circular Messenger DNA

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Abstract

Formyl-methionyl-tRNA is bound to ribosomes by single stranded circular DNA of the phage fd. Addition of neomycin B to this complex permits direct translation of this DNA into protein, which implies that ribosomes do not require a free end on the messenger to initiate protein synthesis.

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Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge

    MARK S. BRETSCHER

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  1. MARK S. BRETSCHER
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BRETSCHER, M. Direct Translation of a Circular Messenger DNA. Nature 220, 1088–1091 (1968). https://doi.org/10.1038/2201088a0

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  • DOI: https://doi.org/10.1038/2201088a0

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