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Prolonged Survival in Heterografted Kidneys with Transplantation Antigen Pretreatment

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Abstract

SUBCELLULAR fractions of donor specific rabbit liver biopsy antigens alone have been used to prolong the survival of kidney allografts in rabbits pretreated for 5 weeks1. Pretreatment with specific histocompatibility antigens in large2 and small (personal communication from R. E. Wilson, A. Rippin, C. R. Hayes, R. K. Dagher and G. J. Busch) doses when combined with small doses of immunosuppressants has prolonged the survival time of kidney allografts in dogs pretreated for 2 weeks. Rat kidney allografts have shown prolonged survival using a combination of a large single dose of donor antigens with antiserum against that antigen 1 day before allografting, together with continued injections of the antiserum alone continued on alternate days for 60 days3. Prolonged survival of rat kidney allografts has also been reported4 following the exhibition of large doses of subcellular fractions of donor specific antigens beginning on the day of grafting and continued on 5 out of 7 days for the next 2 weeks.

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References

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Authors and Affiliations

  1. Children's Medical Research Foundation, Royal Alexandra Hospital for Children, Camperdown, 2050, New South Wales

    EARL R. OWEN

  2. Department of Surgery, University of Sydney,

    EARL R. OWEN

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  1. EARL R. OWEN
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OWEN, E. Prolonged Survival in Heterografted Kidneys with Transplantation Antigen Pretreatment. Nature 219, 970–971 (1968). https://doi.org/10.1038/219970a0

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