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Radiation Enhancement of SV40 Transformation in 3T3 and Human Cells

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Abstract

RADIATION1 and viruses2 are implicated in carcinogenesis in man and animals. Kaplan3 has shown that in radiation induced leukaemia in C57Bl mice a virus present in the animal's tissues is the causative agent. Radiation can increase an animal's susceptibility to tumour production by a virus. The direct effect of radiation on the susceptibility of individual cells to tumour viruses can be tested in tissue culture.

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Authors and Affiliations

  1. National Center for Radiological Health, Rockville, Maryland

    EDWARD J. POLLOCK

  2. National Cancer Institute, Bethesda, Maryland

    GEORGE J. TODARO

Authors
  1. EDWARD J. POLLOCK
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  2. GEORGE J. TODARO
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POLLOCK, E., TODARO, G. Radiation Enhancement of SV40 Transformation in 3T3 and Human Cells. Nature 219, 520–521 (1968). https://doi.org/10.1038/219520a0

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  • DOI: https://doi.org/10.1038/219520a0

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