Abstract
CELLS of the adrenal cortex have a membrane potential of −65 mV to −70 mV (ref. 1). No significant shift of this potential was apparent when steroidogenesis was stimulated by adrenocorticotrophin (ACTH) in normal Krebs–Henseleit medium2. In recent experiments with rabbit adrenal glands, using methods described previously1,2, we have observed that in medium free of K+, ACTH caused depolarization and often induced action potentials in adrenocortical cells.
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References
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MATTHEWS, E., SAFFRAN, M. Effect of ACTH on the Electrical Properties of Adrenocortical Cells. Nature 219, 1369–1370 (1968). https://doi.org/10.1038/2191369a0
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DOI: https://doi.org/10.1038/2191369a0
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