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Cytotoxic and Antifungal Agents: their Body Distribution and Tissue Affinity

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Abstract

WE have described1 a method of investigating the distribution in the body of antibacterial drugs. This is based on the inoculation of thin sections of tissue samples of various organs with a suitable microbe and on the visualization, after incubation, of zones of microbial survival by means of triphenyltetrazolium. We subsequently pointed out2 the possibilities of using the whole body sagittal technique for quickly obtaining information about the general distribution of drugs. Recently3 we suggested the possibility of using the method for studying antifungal and antineoplastic agents. The present communication deals with the evaluation of the distribution and tumour affinity of antifungal and cytotoxic drugs in the body using microbes and yeasts; the use of such organisms for evaluating cytotoxic drugs is justified by their well known effect on these micro-organisms4–9.

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Authors and Affiliations

  1. Research Department, Dott. R. Ravasini and Co., Rome

    EZIO TUBARO & MATIAS JORGE BULGINI

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  1. EZIO TUBARO
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  2. MATIAS JORGE BULGINI
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TUBARO, E., BULGINI, M. Cytotoxic and Antifungal Agents: their Body Distribution and Tissue Affinity. Nature 218, 395–396 (1968). https://doi.org/10.1038/218395a0

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  • DOI: https://doi.org/10.1038/218395a0

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