Skip to main content
SpringerLink
Log in

RNA Synthesis in Yeast Mitochondria: a Derepressible Activity

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

RNA polymerase activity has been observed in isolated mitochondria of Saccharomyces cerevisiae. Increase in this activity precedes that of other respiratory enzymes, and may be of functional significance in mitochondriogenesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Tewari, K. K., Jayaraman, J., and Mahler, H. R., Biochem. Biophys. Res. Commun., 21, 141 (1965); Tewari, K. K., Voetsch, W., Mahler, H. R., and Mackler, B., J. Mol. Biol., 20, 453 (1966).

    Article  CAS  PubMed  Google Scholar 

  2. Corneo, G., Moore, C., Sanadi, D. R., Grossman, L. I., and Marmur, J., Science, 151, 697 (1966).

    Article  ADS  Google Scholar 

  3. Moustacchi, and Williamson, H., Biochem. Biophys. Res. Commun., 23, 56 (1966).

    Article  CAS  PubMed  Google Scholar 

  4. Mounolou, J. C., Jakob, H., and Slonimski, P. P., Biochem. Biophys. Res. Commun., 24, 218 (1966).

    Article  CAS  PubMed  Google Scholar 

  5. Avers, C. J., Proc. US Nat. Acad. Sci., 58, 620 (1967).

    Article  ADS  CAS  Google Scholar 

  6. Sinclair, J. H., Stevens, B. J., Sanghavi, P., and Rabinowitz, M., Science, 156, 1234 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Luck, D. J. L., and Reich, E. P., Proc. US Nat. Acad. Sci., 52, 831 (1964).

    Article  Google Scholar 

  8. Borst, P., Kroon, A. M., and Ruttenberg, G. J. C. M., Genetic Elements, Properties and Function; Symposium Third Meeting FEBS (edit. by Shugar, D.), 81 (Academic Press, New York, 1967).

    Google Scholar 

  9. Granick, S., and Gibor, A., in Progress in Nucleic Acid Research and Molecular Biology (edit. by Davidson, J. N., and Cohn, W. E.), 6, 143 (1967).

    Google Scholar 

  10. Roodyn, D. B., and Wilkie, D., The Biogenesis of Mitochondria (Methuen Co., London, 1968).

    Google Scholar 

  11. Wintersberger, E., in Regulation of Metabolic Processes in Mitochondria (edit. by Tager, J. M., Papa, S., Quagliarello, E., and Slater, E. C.), 439 (Elsevier, Amsterdam, London, New York, 1966).

    Google Scholar 

  12. Rogers, R. J., Preston, B. N., Titchener, E. B., and Linnane, A. W., Biochem. Biophys. Res. Commun., 27, 405 (1967).

    Article  CAS  PubMed  Google Scholar 

  13. Leon, S., and Mahler, H. R., Arch. Biochem. Biophys. (in the press).

  14. Rifkin, M. R., Wood, D. D., and Luck, D. J. L., Proc. US Nat. Acad. Sci., 58, 1025 (1967).

    Article  ADS  CAS  Google Scholar 

  15. Dure, L. S., Epler, J. L., and Barnett, W. E., Proc. US Nat. Acad. Sci., 58, 1883 (1967).

    Article  ADS  CAS  Google Scholar 

  16. Kuntzel, H., and Noll, H., Nature, 215, 1340 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Barnett, W. E., and Brown, D. H., Proc. US Nat. Acad. Sci., 57, 452 (1967).

    Article  ADS  CAS  Google Scholar 

  18. Kalf, G. F., Biochemistry, 3, 1702 (1964).

    Article  CAS  PubMed  Google Scholar 

  19. Neubert, D., and Helge, H., Biochem. Biophys. Res. Commun., 18, 600 (1965).

    Article  CAS  PubMed  Google Scholar 

  20. Tewari, K. K., Jayaraman, J., and Mahler, H. R., in Aspects of Yeast Metabolism, Guinness Symposium, Dublin, 1965 (edit. by Mills, A. K.), 247 (Blackwell, Oxford, 1967).

    Google Scholar 

  21. Suyama, Y., and Eyer, J., J. Biol. Chem., 243, 320 (1968).

    CAS  PubMed  Google Scholar 

  22. Ephrussi, B., Slonimski, P. P., Yotsuyanagi, Y., and Tavlitzki, J., C.R. Lab. Carlsberg Ser. Physiol. 26, 87 (1956).

    Google Scholar 

  23. Jayaraman, J., Cotman, C., Mahler, H. R., and Sharp, C., Arch. Biochem. Biophys., 116, 224 (1966).

    Article  CAS  PubMed  Google Scholar 

  24. Reviewed by Elson, D., Ann. Rev. Biochem., 34, 449 (1965).

    Article  CAS  PubMed  Google Scholar 

  25. So, A. G., Davie, E. W., Epstein, R., and Tissierès, A., Proc. US Nat. Acad. Sci., 58, 1739 (1967).

    Article  ADS  CAS  Google Scholar 

  26. Widnell, C. C., and Tata, J. R., Biochim. Biophys. Acta, 87, 478 (1966).

    Article  Google Scholar 

  27. Hurwitz, J., Furth, J. J., Malamy, M., and Alexander, M., Proc. US Nat. Acad. Sci., 48, 1222 (1962).

    Article  ADS  CAS  Google Scholar 

  28. Waring, M. J., Symp. Soc. Gen. Microbiol., 16, 237 (1966).

    Google Scholar 

  29. Maitra, U., Nakata, Y., and Hurwitz, J., J. Biol. Chem., 242, 4908 (1967).

    CAS  PubMed  Google Scholar 

  30. Reich, E., and Goldberg, I. H., in Prog. Nucleic Acid Res. and Mol. Biol., 3, 184 (1964).

    Google Scholar 

  31. Parenti, F., and Marguiles, M., Fed. Proc., 26, 1102 (1967).

    Google Scholar 

  32. Holley, R. W., Madison, J. T., and Zamir, A., Biochem. Biophys. Res. Commun., 17, 389 (1964).

    Article  CAS  Google Scholar 

  33. Klingenberg, M., and Pfaff, E., in Regulation of Metabolic Processes in Mitochondria (edit. by Tager, J. M., Papa, S., Quagliarello, E., and Slater, E. C.), 180 (Elsevier, Amsterdam, London, New York, 1966).

    Google Scholar 

  34. Caplan, A. I., and Greenawalt, J. W., J. Cell Biol., 16, 15 (1968).

    Article  Google Scholar 

  35. Bachmann, E., Allmann, D. W., and Green, D. E., Arch. Biochem. Biophys., 115, 153 (1965); Allmann, D. W., Bachmann, E., and Green, D. E., ibid., 115, 165 (1966).

    Article  Google Scholar 

  36. Canellakis, E. S., Biochim. Biophys. Acta, 23, 217 (1957).

    Article  CAS  PubMed  Google Scholar 

  37. Sandell, S., Löw, H., and Decken, A. v. d., Biochem. J., 104, 67 (1967) vs Beattie, D. S., Basford, R. E., and Koritz, S. B., J. Biol. Chem., 242, 3366 (1967), and references cited therein.

    Article  Google Scholar 

  38. Neubert, D., Helge, H., and Merker, H. J., Biochem. Z., 343, 44 (1965).

    CAS  PubMed  Google Scholar 

  39. Slonimski, P. P., Symp. Soc. Gen. Microbiol., 3, 76 (1953) and earlier references cited therein.

    Google Scholar 

  40. Ephrussi, B., Nucleo-cytoplasmic Relations in Microorganisms (Clarendon Press, Oxford, 1953).

    Google Scholar 

  41. Roodyn, D. B., and Wilkie, D., The Biogenesis of Mitochondria, 85 (Methuen Co., London, 1968).

    Google Scholar 

  42. Witt, I., Kronau, R., and Holzer, H., Biochim. Biophys. Acta, 118, 522 (1966).

    Article  CAS  PubMed  Google Scholar 

  43. Ferguson, jun., J. J., Boll, M., and Holzer, H., Europ. J. Biochem., 1, 21 (1967).

    Article  CAS  PubMed  Google Scholar 

  44. Utter, M. F., Duell, E. A., and Bernofsky, C., in Aspects of Yeast Metabolism, Guinness Symposium, Dublin, 1965 (edit. by Mills, A. K.), 197 (Blackwell, Oxford, 1967).

    Google Scholar 

  45. Duntze, W., Neumann, D., and Holzer, H., European J. Biochem. 3, 326 (1968).

    Article  CAS  Google Scholar 

  46. Fukuhara, H., Biochim. Biophys. Acta, 134, 143 (1967).

    Article  CAS  Google Scholar 

  47. Fukuhara, H., Proc. US Nat. Acad. Sci., 58, 1065 (1967).

    Article  ADS  CAS  Google Scholar 

  48. Bollum, J. Biol. Chem., 234, 2733 (1959).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chemical Laboratories, University of Indiana,

    DOROTHY J. SOUTH & H. R. MAHLER

Authors
  1. DOROTHY J. SOUTH
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. R. MAHLER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SOUTH, D., MAHLER, H. RNA Synthesis in Yeast Mitochondria: a Derepressible Activity. Nature 218, 1226–1232 (1968). https://doi.org/10.1038/2181226a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2181226a0

  • Springer Nature Limited

This article is cited by

Search

Navigation