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Haemoglobin Variant in a Bushman: Haemoglobin Dβ-Bushmanαβ2216Gly→Arg

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Abstract

VARIANTS of human haemoglobin A with an electrophoretic mobility identical with Hb-S at pH 8.6, but not causing sickling, are designated HbD. This type of haemoglobin has been found in many widely separated geographical localities1. In six cases the haemoglobins D were structurally identical with the substitution glutamic acid→glutamine at position 121 of the β-chain2,3. These samples were obtained from a Punjabi, a Caucasian from North Carolina, an Italian family living in Chicago, a Portuguese, a Greek Cypriot and a white family living in Los Angeles in whom Hb-S was also present.

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Authors and Affiliations

  1. Department of Anthropology, University College, University of London,

    PATRICIA T. WADE

  2. S. A. Institute for Medical Research, Johannesburg

    T. JENKINS

  3. MRC Group in Haemolytic Anaemia, University College Hospital Medical School, London, WC1

    E. R. HUEHNS

Authors
  1. PATRICIA T. WADE
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  2. T. JENKINS
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  3. E. R. HUEHNS
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WADE, P., JENKINS, T. & HUEHNS, E. Haemoglobin Variant in a Bushman: Haemoglobin Dβ-Bushmanαβ2216Gly→Arg. Nature 216, 688–690 (1967). https://doi.org/10.1038/216688b0

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  • DOI: https://doi.org/10.1038/216688b0

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