Abstract
THREE principal groups of mucopolysaccharides—hyaluronic acid, heparan sulphates, and chondroitin sulphates—exist in the ground substance of the human arterial wall. Their relative proportions change with age1,2, blood pressure2 and arterial site3 in such a way as to suggest a possible relationship with atherosclerosis.
Similar content being viewed by others
References
Kaplan, D., and Meyer, K., Proc. Soc. Exp. Biol. and Med., 105, 78 (1960)
Manley, G., Brit. J. Exp. Pathol., 46, 125 (1965).
Manley, G., and Hawksworth, J., Nature, 206, 1152 (1965).
Muir, H., Biochem. J., 69, 195 (1958).
Anderson, B., Hoffman, P., and Meyer, K., J. Biol. Chem., 240, 156 (1965).
Rodén, L., and Armand, G., J. Biol. Chem., 241, 65 (1966).
Seno, N., Meyer, K., Anderson, B., and Hoffman, P., J. Biol. Chem., 240, 1005 (1965).
Scott, J. E., Meth. Biochem. Anal., 8, 145 (1960).
Schiller, S., Slover, G. A., and Dorfman, A., J. Biol. Chem., 236, 983 (1961).
Bitter, T., and Muir, H., Anal. Biochem., 4, 330 (1962).
Boas, N., J. Biol. Chem., 204, 553 (1953).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MANLEY, G., MULLINGER, R. Effect of Age on the Amino-acids associated with Vascular Heparan and Chondroitin Sulphates. Nature 216, 603–604 (1967). https://doi.org/10.1038/216603a0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1038/216603a0
- Springer Nature Limited