Skip to main content
SpringerLink
Log in

Influence of Pulmonary Dust Load on the Development of Experimental Infection by Mycobacterium kansasii

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

FOR a long time1 it has been known that the experimental infection of guinea-pigs could be aggravated by exposure to silica particles. Many surveys have tried to specify the interactions: “dust-infection” into lungs. We have determined the pathogenic role of Mycobacterium kansasii in guinea-pigs exposed to the inhalation of mineral dust particles2–7 and have established the following facts. (a) Dust particles aggravate experimental infection by Mycobacterium kansasii, and dusting is liable to make pathogenic a certain dose of bacteria which, without dust, would not induce lesions. (b) There is increased severity of the pulmonary lesions when there is dusting before, but not after the inoculation of an infecting dose of about 5 × 105 micro-organisms. (c) The previously established absence8–11 of increased virulence of the strains after passage and extensive multiplication in dusted animals is confirmed and so is (d) the exacerbation arid precociousness of tuberculin-allergy after the double aggression of dust and mycobacterial infection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Cesa-Bianchi, D., Z. Hyg. Infekt. Kr., 73, 166 (1913).

    Google Scholar 

  2. Gernez-Rieux, Ch., and Tacquet, A., and Macquet, V., Ann. Inst. Pasteur Lille, 10, 9 (1958–1959).

    PubMed  Google Scholar 

  3. Gernez-Rieux, Ch., and Tacquet, A., Bull. Un. Intern. Tuberc., 29, 330 (1959).

    Google Scholar 

  4. Policard, A., Gernez-Rieux, Ch., Tacquet, A., Collet, A., Martin, J. C., and Devulder, B., Pathol. Biol., 15, 257 (1967).

    CAS  PubMed  Google Scholar 

  5. Tacquet, A., Collet, A., Macquet, V., Martin, J. C., Gernez-Rieux, Ch., and Policard, A., C.R .Acad. Sci., 257, 3103 (1963).

    CAS  Google Scholar 

  6. Tacquet, A., Collet, A., Devulder, B., Martin, J. C., Policard, A., and Gernez-Rieux, Ch., Pathol. Biol., 14, 781 (1966).

    Google Scholar 

  7. Tacquet, A., Collet, A., Martin, J. C., Devulder, B., and Gernez-Rieux, Ch., Pathol. Biol., 14, 790 (1966).

    Google Scholar 

  8. Gardner, L. U., Proc. Intern. Silicosis Conference, Johannesburg (1930).

  9. King, E. J., and Gilchrist, M., MRC Special Rep., 250, 24 (1945).

  10. Steenken, jun., W., Raleigh, J., and Smith, M. M., Amer. Rev. Resp. Dis., 83, 208 (1961).

    Google Scholar 

  11. Vorwald, A. J., Dworski, M., Pratt, P. C., and Delahant, A. B., Amer. Rev. Tuberc., 69, 766 (1954).

    CAS  Google Scholar 

  12. Byers, P. D., and King, E. J., J. Pathol. Bact., 81, 123 (1961).

    CAS  Google Scholar 

  13. King, E. J., Sivalingam, S., and Trevella, W., Arch. Environ. Health, 7, 33 (1963).

    CAS  PubMed  Google Scholar 

  14. King, E. J., Analyst, 80, 441 (1955).

    ADS  CAS  Google Scholar 

  15. Policard, A., Letort, M., Charbonnier, J., Martin, J. C., and Daniel-Moussard, H., C.R. Acad. Sci., 263, 696 (1966).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut Pasteur de Lille and Centre d'Etudes et Recherches des Charbonnages de France, Verneuil-en-Halatte,

    A. POLICARD, CH. GERNEZ-RIEUX, A. TACQUET, J. C. MARTIN, B. DEVULDER & L. LE BOUFFANT

Authors
  1. A. POLICARD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. CH. GERNEZ-RIEUX
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. TACQUET
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. C. MARTIN
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. B. DEVULDER
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. L. LE BOUFFANT
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

POLICARD, A., GERNEZ-RIEUX, C., TACQUET, A. et al. Influence of Pulmonary Dust Load on the Development of Experimental Infection by Mycobacterium kansasii. Nature 216, 177–178 (1967). https://doi.org/10.1038/216177a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/216177a0

  • Springer Nature Limited

Search

Navigation