Abstract
THE absence of a generally applicable pharmacological method for estimating the potency of potentiating compounds such as anticholinesterases and antiamine oxidases is perhaps partly a result of the accuracy with which these compounds can be assayed by manometric techniques on isolated enzymes. Inhibitory potency determined in this way, however, is not necessarily indicative of the potentiating activity to be found in the whole animal or even in isolated tissues.
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References
Schild, H. O., Brit. J. Pharmacol. Chemotherap., 2, 189 (1947).
Smith, C. M., Cohen, H. L., Pelikan, E. W., and Unna, K. R., J. Pharmacol. Exp. Therap., 105, 391 (1952).
Smith, C. M., Mead, J. C., and Unna, K. R., J. Pharmacol. Exp. Therap., 120, 215 (1957).
Edge, N. D., Arch. Intern. Pharmacodyn., 95, 428 (1953).
Quilliam, J. P., and Strong, F. G., Brit. J. Pharmacol. Chemotherap., 4, 168 (1949).
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EDGE, N. pPy: a Measure of Potentiating Activity. Nature 216, 1014–1015 (1967). https://doi.org/10.1038/2161014a0
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DOI: https://doi.org/10.1038/2161014a0
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