Skip to main content
SpringerLink
Log in

Elimination of Normal Horse IgG labelled with Iodine-131 in Rats receiving Horse Anti-rat Lymphocytic IgG

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

RECENT reports have indicated that antilymphocytic IgG, in addition to inhibiting the homograft reaction, is capable of suppressing the formation of humoral antibody against a number of antigens1–4. Somewhat conflicting results have appeared, however, on the ability of antilymphocytic antibody to suppress the formation of antibody against itself, or against normal IgG globulin obtained from the species in which the antibody was produced5–7. We have investigated this problem by studying the effect of prolonged administration of antilymphocytic IgG (horse anti-rat) on the elimination of normal horse IgG, labelled with iodine-131, from rats.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gray, J. G., Monaco, A. P., and Russell, P. S., Surg. Forum, 15, 142 (1964).

    CAS  PubMed  Google Scholar 

  2. Monaco, A. P., Wood, M. L., Gray, J. G., and Russell, P. S., J. Immunol., 96, 229 (1966).

    CAS  PubMed  Google Scholar 

  3. James, K., and Anderson, N. F., Nature, 213, 1195 (1967).

    Article  ADS  Google Scholar 

  4. James, K., and Jubb, V. S., Nature, 215, 367 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Gray, J. G., Monaco, A. P., Wood, M. L., and Russell, P. S., J. Immunol. 96, 217 (1966).

    CAS  PubMed  Google Scholar 

  6. Currey, M. L. F., and Ziff, M. P., Lancet, ii, 889 (1966).

  7. Iwasaki, Y., Porter, K. A., Amond, J. R., Marchioro, T. L., Zuhlka, V., and Starzl, T. E., Surg. Gynec. Obstet., 124, 1 (1967).

    CAS  PubMed  Google Scholar 

  8. Anderson, N. F., James, K., and Woodruff, M. F. A., Lancet, i, 1126 (1967).

  9. Hunter, W. M., and Greenwood, F. C., Nature, 194, 495 (1962).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Woodruff, M. F. A., and Anderson, N. F., Ann. NY Acad. Sci., 120, 119 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Woodruff, M. F. A., The Transplantation of Tissues and Organs, 101 (Thomas, Springfield, 1960).

    Google Scholar 

  12. Lance, E., and Dresser, D. W., Nature, 215, 488 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgical Science, University of Edinburgh, MRC Research Group on Clinical and Experimental Problems of Transplantation,

    J. G. CLARK, K. JAMES & M. F. A. WOODRUFF

Authors
  1. J. G. CLARK
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. JAMES
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. F. A. WOODRUFF
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

CLARK, J., JAMES, K. & WOODRUFF, M. Elimination of Normal Horse IgG labelled with Iodine-131 in Rats receiving Horse Anti-rat Lymphocytic IgG. Nature 215, 869–870 (1967). https://doi.org/10.1038/215869a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/215869a0

  • Springer Nature Limited

This article is cited by

Search

Navigation