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Increase of Cerebral Catecholamines caused by 3,4-Dihydroxyphenylalanine after Inhibition of Peripheral Decarboxylase

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Abstract

N-(DL-seryl)-N′-(2,3,4-trihydroxybenzyl)-hydrazine (HCl) (Ro 4-4602) is a strong inhibitor of decarboxylase of aromatic amino-acids in vivo and in vitro1,2. The drug counteracts the increase of 5-hydroxytryptamine which is induced by 5-hydroxytryptophan less markedly in the brain than in extracerebral organs. Small doses of Ro 4-4602 have even seemed to enhance this transformation in the brain; this effect could not be explained3,4.

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Authors and Affiliations

  1. Medical Research Department, F. Hoffmann-La Roche and Co., Ltd., Basle

    G. BARTHOLINI, W. P. BURKARD & A. PLETSCHER

  2. Pharmacology Department, Hoffmann-La Roche, Inc., Nutley, New Jersey

    H. M. BATES

Authors
  1. G. BARTHOLINI
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  2. W. P. BURKARD
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  3. A. PLETSCHER
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  4. H. M. BATES
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BARTHOLINI, G., BURKARD, W., PLETSCHER, A. et al. Increase of Cerebral Catecholamines caused by 3,4-Dihydroxyphenylalanine after Inhibition of Peripheral Decarboxylase. Nature 215, 852–853 (1967). https://doi.org/10.1038/215852b0

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  • DOI: https://doi.org/10.1038/215852b0

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